Scientists prove: additional activity in the production of free of radicals. A new research result, supported by NSE, to internal causes of aging, has identified a previously unknown source of superoxide free radicals. Free radicals by external triggers, such as exposing the solar radiation, cigarette smoke, are long known to the skin cells and components of extracellular (lying outside the cell) matrix, including collagen and elastin, to damage. NSE and Purdue University scientists report on their new research findings of regarding age-related NADH oxidase (arNOX) this week in Kyoto, Japan, on the international investigative dermatology 2008, a major event for the latest information about the biology of the skin. Scientists explain the conclusive evidence that arNOX, an enzyme which is related to cell membranes, skin cells and is active. The arNOX activity increases considerably during the Advanced”years of approximately 45 to 70 years. A breakthrough discovery in understanding the aging is the identification of arNOX as the skin-Dungeness and its growing activity with age, “explains Dr.
med. Zoe Diana Draelos, research Chairman of Dermatology consulting services, the NSE Scientific Advisory Board member (NSE Scientific Advisory Board) and one of the authors of the study. Currently the dermatological research focuses on the correction of skin damage, after they are created. By recognizing the internal source of free radicals in the skin and if you closer to understanding, why and how they are produced, then our ability contributes, to address the basic mechanisms that are available, possibly in conjunction with external sources to the accelerated aging lead.”the detection of arNOX in the skin allows further insights into the potential revolutionary treatments for skin care. In particular, because its activity relating to the years, if the People are beginning to see how their skin loses its elasticity and firmness, and you notice the fading of her complexion and wrinkles,”notes Dr.
phil. Helen Knaggs on, Vice President of NSE global research and development (NSE global research and development). “If we can pursue innovative ways to curtail the activity of arNOX and especially the production of free radicals to stop, then we can talk on both sides of the equation: the damage caused by free radicals of external sources right, while at the same time prevents the production of free radicals from internal sources.” The study’s authors are Dale Kern, Chief Scientist at NSE, Dr. phil. Dorothy Morre, Professor of foods and nutrition at Purdue University, and Dr. phil. D. James Morre, Dow Honorary Professor in pharmaceutical chemistry of at Purdue University. Since 1999, the NSE and the Morres ENOX research have supported and promoted. About arNOX: The arNOX enzyme belongs to a class of newly discovered and certain ECTO-NOX (external NADH oxidase or ENOX)-proteins, which are stored on external (outer) cell membranes. ECTO-NOX proteins become increasingly active to generate additional metabolic energy, such as the age of mitochondria, and produce less energy. arNOX has been proven in all cells tested, including serum, saliva and then DermIS (DermIS) and the skin (epidermis). Its unique feature is that it generates superoxide on the cell surface, which is able to damage adjacent cells, lipoproteins and other structural components of the extracellular matrix of the skin, such as collagen and elastin. Other NOX categories include the tumor-NOX, viral NOX and the Basic or normal NOX. About the international investigative dermatology 2008 is the fifth joint meeting of the society of Investigative Dermatology (SID), the European society for Dermatology research (ESDR) and the Japanese society for Investigative Dermatology (JSID).